NK For Cancer

Breast Cancer

Natural KILLER CELL THERAPY

Protocol with Natural Killer Cells for Breast Cancer

Breast cancer is a disease characterized by the formation and growth of malignant (cancer) cells in the aside from skin cancer.

A wide variety of studies have shown that a family history of breast cancer increases the likelihood of developing this disease, however, it is not the only one; since environmental, physical and dietary factors can also increase the risk of developing breast cancer.

The signs of breast cancer include a mass or a change in the tissue that forms the breast, therefore, to diagnose breast cancer, tests are used to examine the breasts and if signs that indicate the possibility of cancer are found, cellular, molecular and genetic tests are done to confirm the result. The classic therapies or treatments for breast cancer include Surgery, Radiotherapy, Chemotherapy, Hormone therapy, Targeted therapy and Immunotherapy with natural killer cells.

Natural Killer (NK) Cells

They are granular lymphoid cells belonging to the innate immune system and play a fundamental role in the early defense against viral infections and abnormal (tumor) cells; together with the adaptive immune system they structure an organized response to eliminate malignant cells.
NK cells and their role in breast cancer

Several studies have focused on the relationship between the activity of NK cells and breast cancer (BC), demonstrating a low or null activity (functionality) of these cells in patients with BC, compared to healthy individuals.

Patients with functional defects and a low number of NK cells have a higher risk of developing a more aggressive and difficult-to-control breast cancer. The presence of a significant number of NK cells can function as a prognostic factor.

Research to date suggests that, given the progressive decrease in cell functionality in relation to the severity of the patient’s condition, these could be used as a tool to indirectly identify the stage or possible progression of a precancerous lesion to a tumor stage. However, given the multifactorial nature of oncological pathologies, this parameter should be confirmed and completed with other studies.
Currently, there are just over 30 clinical trials in development where NK cells are used with different technological strategies: from autologous NK to genetically modified cells (CAR-NK). Most of these have yielded important results in the control and restriction of metastatic processes. However, further research is still required.
The general treatment scheme starts at 2-5 million per kilogram of patient, but it directly depends on the patient’s general condition and the stage of progression in which he or she is. Thus, the following scheme represents a basic treatment for an initial/intermediate stage.
  • 3 applications (100 million) of Natural Killer cells
  • Weekly intravenous application of 100 million NK Cells, or treatment every other day for 5 days until the treatment is complete.

Once the patient’s complete medical history and review have been completed, and the therapeutic regimen has been determined, the patient is given the informed consent letter to be signed and an appointment is provided for the start of therapy.

Application process

  • The application takes place in R3 Stem Cell’s offices in Mexico or Pakistan, where the patient is invited to take a comfortable position and the IV is placed in the arm.
  • The drip is regulated to deliver the 100 mL saline solution in 30-40 minutes.
  • Once the dose is finished, the IV equipment is removed.
  • The patient is left at rest and under medical observation for 20 minutes.

Adverse Effects

Regimes of 2-5 million cells per kg have occasionally resulted in these side effects:

  • Low-grade fever
  • Headache
  • Fatigue
  • Dizziness

Follow-up:

It is recommended to perform laboratory and office tests within 10 days of completing the first application regimen, or at least 2 months after the first application.

R3 Stem Cell offers Natural Killer Cell Therapy in Tijuana Mexico with donor cells (allogeneic) and in Islamabad Pakistan with a patient’s own NK Cells (autologous). Call R3 today at +1 (844) 4NK-CELL to set up your free consultation!

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