April 2026

What Are Natural Killer Cells? The Immune System’s First Responders Written by Dr. David Greene, MD, PhD, MBA Introduction The human immune system is a complex, multi-layered defense network that operates around the clock to protect us from pathogens, cancerous cells, and other threats. While much attention has been given to T cells and B cells […]

Adoptive NK Cell Transfer: Infusing Immunity to Fight Disease Written by Dr. David Greene, MD, PhD, MBA Introduction Adoptive cell transfer therapy involves taking immune cells — either from the patient or from a healthy donor — growing them in large numbers in a laboratory, and then infusing them back into a patient to fight disease.

Written by Dr. David Greene, MD, PhD, MBA Introduction Chimeric Antigen Receptor T cell therapy — better known as CAR-T — has been one of the most celebrated breakthroughs in oncology over the past decade. By genetically engineering T cells to carry a synthetic receptor that recognizes cancer-specific surface molecules, CAR-T therapy has achieved remarkable remissions

The Missing-Self Hypothesis: How NK Cells Tell Friend from Foe Written by Dr. David Greene, MD, PhD, MBA Introduction In the world of immunology, few concepts are as elegant — and as clinically important — as the missing-self hypothesis. First proposed by Dr. Klas Kärre in the 1980s, this theory explains how Natural Killer cells identify

What Are Natural Killer Cells? The Immune System’s First Responders Written by Dr. David Greene, MD, PhD, MBA Introduction The human immune system is a complex, multi-layered defense network that operates around the clock to protect us from pathogens, cancerous cells, and other threats. While much attention has been given to T cells and B cells